Anti- N-MethyL-D-Aspartate Receptor Encephalitis in Children Infected with Herpes Simplex

Herpes Simplex Virus (HSV) is a common cause of infectious encephalitis in children, which can lead to severe neurological sequels. There new perspective suggesting that herpes simplex plays an important role triggering the synthesis NMDA receptor antibodies. have been no data on incidence anti-NMDA Indonesia. was found these patients as risk factor for encephalitis. A 9-year-old male patient complained seizures such jerking right hand and smacking lips along with fever 4 days before being admitted hospital. Complaints began slurred speech t inability fingers hold objects previous 8 days. From physical examination, it reported looked seriously ill, blood pressure 110/80 mmHg, pulse 117 beats per minute, temperature 38.5 C, respiratory rate 24 times minute. Another examination within normal limits. The results complete count at time initial treatment showed mild leukocytosis due increase monocytes, whereas gas electrolyte analysis hypoventilation beginning hospitalization mixed acid-base disturbance, acidosis, metabolic alkalosis occurred. Analysis cerebrospinal fluid mononuclear pleocytosis immunoserological test serum indicated HSV1 HSV2 infection detected receptor. Both clinical laboratory findings this study supported virus be suffering from